Chronic pain

Chronic painis an autoimmune condition where the immune system attacks the thyroid gland, gradually reducing its ability to produce thyroid hormone. It's the most common cause of hypothyroidism in the U.S. and disproportionately affects women.

Reviewed by editorial board · Updated May 2026

Common symptoms

  • Persistent fatigue
  • Weight gain
  • Cold intolerance
  • Hair thinning
  • Dry skin
  • Brain fog
  • Constipation
  • Joint & muscle aches

How it's typically diagnosed

Diagnosis is based on a combination of symptom presentation and laboratory findings — typically elevated TPO and/or thyroglobulin antibodies, along with TSH and free T4. Many holistic practitioners also run free T3, reverse T3, ferritin, and selenium to build a fuller picture.

Approaches to treatment

Conventional

Levothyroxine (T4 replacement). Periodic TSH monitoring. May add liothyronine (T3) in select cases.

Holistic / functional

Root-cause investigation (gluten/dairy reactivity, gut health, nutrient status), targeted supplementation (selenium, zinc, vitamin D, myo-inositol), and dietary protocols alongside conventional medication.

People also ask

Can Hashimoto's be reversed naturally?+
Antibody levels can often be substantially reduced through diet, supplementation, and addressing underlying triggers. Whether the autoimmune process fully reverses depends on individual factors and is best evaluated with a practitioner.
Do I need to go gluten-free?+
There's increasing evidence of a gluten-Hashimoto's link, particularly in patients with concurrent celiac or non-celiac gluten sensitivity. Many holistic practitioners recommend a trial elimination of 60–90 days to evaluate.
What's the difference between Hashimoto's and hypothyroidism?+
Hashimoto's is the autoimmune cause; hypothyroidism is the resulting condition (underactive thyroid). Most U.S. hypothyroidism is caused by Hashimoto's, but not all.